Using Deliberate Cold Exposure to Boost Brown Fat Thermogenesis

All Things NAD+: A Deep Dive into Nicotinamide Adenine Dinucleotide

# Introduction

We take a fresh perspective on raising NAD+ levels, examining:

• What NAD+ is and how it functions in the human body
• Enzymes that consume NAD+ and how it's synthesized and recycled
• The impact of low NAD+ levels on aging humans
• Strategies for optimizing NAD+ levels

# Benefits of a 72-Hour Monthly Fast

Engage in a monthly 72-hour fast to significantly boost NAMPT activation and CD38 inhibition. Benefits include:

• Increased autophagy
• Enhanced ketosis
• Potential for substantial NAD+ level improvement

# JINFINITY'S Intracellular NAD Test

For more information or to purchase JINFINITY'S Intracellular NAD Test, use code LANCE for a 10% discount: JINFINITY NAD Test

# Connect with Lance Hitchings

• Website
• "The Longevity Guide" Online Course
• Longevity Coaching
• Patreon

# Social Media

• YouTube
• Facebook
• Instagram
• X (Formerly Twitter)
• LinkedIn

# Affiliate Links

• Trudiagnostic (Discount code: LANCE): Website
• Renue By Science (Discount code: LANCE10): Product Links
• DoNotAge (Discount code: LANCE):
  • Annual Subscription
  • Products
• Perfect Amino (Discount code: HITCH10): Website
• Get a free month of Whoop

# Video Chapters & Timestamps

• Intro: 00:00
• What Is NAD+: 00:55
• How Does NAD+ Impact Aging: 07:51
• What Can You Do To Raise NAD+ Levels: 09:01
• FREE Training: 12:25
• A 4-Pronged Approach To Raising NAD+ Levels: 13:31

# Studies Referenced

1. Aerobic and resistance exercise training reverses age-dependent decline in NAD+ salvage capacity in human skeletal muscle

2. Skeletal muscle NAMPT is induced by exercise in humans

3. Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals

4. NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health

5. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders

6. Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells

7. Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis

8. NAD+ metabolism and its roles in cellular processes during ageing

9. A systems-approach to NAD+ restoration

Lifestyle habits from Matt Walker to adopt into your daily routine to improve deep sleep, wake up feeling refreshed, reduce cravings, and promote lasting brain and body wellness.

All Things NAD+: A Deep Dive into Nicotinamide Adenine Dinucleotide

# Introduction

We take a fresh perspective on raising NAD+ levels, examining:

• What NAD+ is and how it functions in the human body
• Enzymes that consume NAD+ and how it's synthesized and recycled
• The impact of low NAD+ levels on aging humans
• Strategies for optimizing NAD+ levels

# Benefits of Intermittent Fasting for NAD+

Implement daily intermittent fasting to:

• Activate NAMPT
• Inhibit CD38
• Potentially improve NAD+ levels

Benefits include:

• Increased NAMPT activation
• Improved NAD+ to NADH ratio
• Enhanced cellular energy metabolism

# JINFINITY'S Intracellular NAD Test

For more information or to purchase the test, use code LANCE for a 10% discount: JINFINITY NAD Test

# Resources

• Website
• "The Longevity Guide" Online Course
• Longevity Coaching
• Patreon

# Social Media

• YouTube
• Facebook
• Instagram
• X (Formerly Twitter)
• LinkedIn

# Affiliate Links

• Trudiagnostic (Discount code: LANCE): Website
• Renue By Science (Discount code: LANCE10): Products
• DoNotAge (Discount code: LANCE):
  • Annual Subscription
  • Products
• Perfect Amino (Discount code: HITCH10): Link
• Get a free month of Whoop

# Video Chapters & Timestamps

• Intro: 00:00
• What Is NAD+: 00:55
• How Does NAD+ Impact Aging: 07:51
• What Can You Do To Raise NAD+ Levels: 09:01
• FREE Training: 12:25
• A 4-Pronged Approach To Raising NAD+ Levels: 13:31

# Studies Referenced

1. Aerobic and resistance exercise training reverses age-dependent decline in NAD+ salvage capacity in human skeletal muscle

2. Skeletal muscle NAMPT is induced by exercise in humans

3. Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals

4. NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health

5. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders

6. Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells

7. Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis

8. NAD+ metabolism and its roles in cellular processes during ageing

9. A systems-approach to NAD+ restoration

Learn to improve deep sleep, wake up feeling refreshed, reduce cravings, and promote lasting brain and body wellness by manipulating body temperature and darkness

Insights about caffeine from Professor Matt Walker to adopt into your daily routine to improve deep sleep, wake up feeling refreshed, reduce cravings and promote lasting brain and body wellness.

Using ice baths and cold to enhance recovery and performance

Use deliberate cold and heat exposure to support circadian rhythm for optimal wake and sleep cycles

Protocols from Huberman Lab episode #66 on deliberate use of cold and episode # 69

Use science-backed tools for enhancing focus, learning, creativity, sleep, physical strength and endurance, and brain and body health.

Bulletproof Coffee and Intermittent Fasting

Start your day with a carefully prepared cup of Bulletproof Coffee, designed to potentially enhance your intermittent fasting experience without significantly impacting your fasting state.

# Benefits:

• Increased energy and alertness
• Potential support for fat burning and improved metabolism
• May help with satiety during fasting periods

# Does Bulletproof Coffee Break a Fast?

There are many opinions on whether drinking Bulletproof Coffee in the morning breaks your fast. Let's examine this controversial question and attempt to separate fact from fiction.